These agents induce their cytotoxic effects by targeting

Cisplatin and carboplatinPlatinum agents have currently shown the greatest promise in patients with NSCLC. These agents induce their cytotoxic effects by targeting cellular DNA and are active against a number of tumour types (Go and Adjei, 1999). Cisplatin is thought to act by activating apoptosis and altering a number of other cellular parameters.

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